BCL2 and Parkinson disease: Furthermore, according to Prema et al. [281], lycopene induces increased expression of the antiapoptotic protein B-cell lymphoma 2 protein (BCL-2) and decreased release of the proapoptotic proteins cytochrome c, protein x associated with BCL-2 (BAX), and caspases-3, 8, and 9, preventing apoptosis in mice with PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.