In evaluating the effect of lycopene in an animal model of atherosclerosis, Renju et al. [216] demonstrated that CAT, SOD, and GSH-Px activities and GSH levels were increased, while the levels of thiobarbituric acid reactive substances (TBARS), total cholesterol, triglyceride, low-density lipoprotein (LDL), very-low-density lipoprotein, and inflammatory mediators, including cyclooxygenase-2 (COX-2) and 15-lipoxygenase, decreased after treatment with lycopene isolated from the alga Chlorella marina. Here, PTGS2 is linked to atherosclerosis.