INS and colitis: Insulin-resistant mice fed a high-fat, high-sugar diet supplemented with cyanidin-3-glucoside (C3G) extract, commonly found in blueberries, reduced Erysipelotrichaceae and Streptococcaceae relative abundance [60], a finding similar to this study in which BRB supplementation reduced both Erysipelotrichaceae and Streptococcaceae prior to DSS-induced gut injury and during active colitis, with different outcomes depending on the basal diet provided.