Finally, higher fasting insulin was associated with an elevated risk of endometrial cancer (OR = 3.71, 95% CI 2.06–6.67) (Figure 1C, Table S5) and using an exposure instrument generated from sex-combined data, higher plasma adiponectin was associated with diminished colon cancer risk (OR = 0.50, 95% CI 0.31–0.81). This evidence concerns the gene ADIPOQ and endometrial cancer.