Similarly, the association between BMI and endometrial cancer risk was attenuated when adjusted for BioT or fasting insulin (Figure 1D, Table S6), which influenced the risk of this cancer independent of obesity (BMI-adjusted BioT OR 1.91 [95% CI 1.47–2.48] and insulin OR 2.61 [95% CI 1.44–4.74]). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.