In the context of inflammation associated with GDM, treatment with resveratrol significantly ameliorated the chemical and microbial induction of inflammation and insulin resistance, restored the induced defects in the insulin signaling pathway and glucose uptake, and also significantly reduced the expression and secretion of proinflammatory cytokines (IL-6, IL-1α, IL-1β) and proinflammatory chemokines IL-8 and MCP-1 in human placenta and adipose tissue [121]. The gene discussed is INS; the disease is gestational diabetes.