HFE and Cirrhosis: The HFE SNP, rs1800562 (C282Y) included in this study is known to cause a serious type 1 hereditary hemochromatosis, which most commonly affects the liver and significantly increases the risk of developing cirrhosis when serum ferritin exceeds 1000 ng/mL at diagnosis, according to The American College of Gastroenterology (ACG) Clinical Guideline [33].