Together, these findings suggest that whilst the VDR is biologically impactful in the normal differentiation, for example, the process to monocytes, it is not itself so frequently disrupted in leukemia such that when it is mutated it acts in an oncogenic manner to disrupt normal progenitor differentiation, and it cannot be targeted to induce leukemia cell differentiation in patients. The gene discussed is VDR; the disease is leukemia.