ADAM17 facilitates EGF receptor-, TNF-α receptor-, and IL-6 receptor-mediated signal transduction by cleavage/hydrolysis of the ectodomains of more than 80 membrane proteins (e.g., pro-inflammatory cytokines, adhesion molecules, receptors, and growth factors) and regulates multiple pathophysiological processes, including tumor, inflammation, immunity, growth, and metastasis [16,17,18]. Here, ADAM17 is linked to neoplasm.