GSK3B and Alzheimer disease: It should also be noted that in recent years, despite the investigation and evaluation of multiple complex signaling pathways related to AD neuropathology, such as glycogen synthase kinase-3β (GSK3-β) and the study of the interaction between multiple pathological and risk factors, the discovery of very potent therapies with multifaceted curative properties seems necessary because to date there is no treatment for this disease [3].