MAPK3 and cervical cancer: Likewise, cervix cancer HeLa cells treated with fisetin encouraged a continuous activation of the phosphorylation of ERK1/2, and the inhibition of ERK1/2 or the transfection with the mutant ERK1/2 expression vector suggestively eliminated the fisetin-initiated apoptosis via the activation of the caspase-8, -3 pathway.