The use of scenarios that feature the preventive use of FFIs on alternative in vivo stress models involving molecular-genetic and proteomic approaches to assess the functional state of nuclear transcription factors, c-Jun N-terminal kinases, and signaling of the intracellular antioxidant defense system of neurons will shed light on the understanding of the mechanisms of relieving anxiety and depression by polyphenolic compounds under stress. This evidence concerns the gene JUN and major depressive disorder.