The 14 potential targets of 22-(4′py)-JA in regulating NSCLC apoptosis are shown in Table 1, of which the top three targets ranked by score of the degree were MAPK3 (ERK1), MAPK1 (ERK2) and MAP2K1 (MEK1) (Table S2). Here, MAP2K1 is linked to non-small cell lung carcinoma.