The 14 potential targets of 22-(4′py)-JA in regulating NSCLC apoptosis are shown in Table 1, of which the top three targets ranked by score of the degree were MAPK3 (ERK1), MAPK1 (ERK2) and MAP2K1 (MEK1) (Table S2). This evidence concerns the gene MAPK1 and non-small cell lung carcinoma.