NOTCH1 and non-small cell lung carcinoma: This receptor appears to promote NSCLC cell proliferation by modulating the circ-NOTCH1/YAP1/QKI/ /m6A methylated NOTCH1 pathway, and in this way, the GPER upregulates circNOTCH1, blocks YAP1 phosphorylation, and increases YAP1-TEAD transcriptional regulation on QKI [125] (Figure 2).