Bisphenol A (BPA), a ubiquitous pollutant with endocrine disrupting effects, may increase carcinogenesis susceptibility as treatment with BPA promotes the migration and invasion of human lung cancer cells, an effect linked to morphological changes and matrix MMP-2 and MMP-9 overexpression mediated by GPER [127] (Figure 2). This evidence concerns the gene GPER1 and lung carcinoma.