For instance, GPER is overexpressed in seminomas [58,59], melanomas [189], some ovarian cancers [208], some lung cancers (NSCLC) [124], and in insulin-resistant endometrial cancer models [168] and in most of the breast cancer (particularly TNBC) [11,66,70,75,101] models reported in this paper. This evidence concerns the gene INS and melanoma.