GPER1 and triple-negative breast carcinoma: In triple-negative breast cancer (TNBC), GPER expression is increased and GPER-mediated signaling contributes to TNBC invasiveness, metastasis, and recurrence through mechanisms involving the activation of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3), which mediates alterations in expression of target genes [67].