For example, it was reported in one study covering the epigenetic regulation of GPER in ovarian tumors that GPER activation epigenetically regulates the trimethylation of histone H3 lysine 4 (H3K4me3) and ERK1/2, which leads to cell proliferation and migration inhibition in ovarian cancer cells [218]. This evidence concerns the gene GPER1 and ovarian carcinoma.