Furthermore, tamoxifen could prevent hepatic fibrosis in HCC patients by promoting mechanical deactivation of ECM protein synthesis as well as suppressing actomyosin-dependent contractility and mechanosensing of external tissue stiffness via a GPER-mediated RhoA/myosin signaling in hepatic stellate cells (HSCs) [157]. This evidence concerns the gene RHOA and hepatocellular carcinoma.