GPER stimulation activates yes-associated protein 1 (YAP1) and transcriptional coactivator with a PDZ-binding domain (TAZ), two homologous transcription coactivators and key effectors of the Hippo tumor suppressor pathway, via the Gαq-11, PLCβ/PKC, and Rho/ROCK signaling pathways. The gene discussed is GPER1; the disease is neoplasm.