We found that compounds O2N-BZM7 and O2N-BZM9 have the most promising effects against giardiasis and trichomoniasis since they inactivate the G6PD::6PGL enzymes of both parasites, alter their structures, and efficiently cause the death of G. lamblia and T. vaginalis trophozoites. The gene discussed is G6PD; the disease is Trichomonas vaginitis urogenital infection.