These results described that Kmp downregulates RhoA protein and activates Rac-1 among TNB cancer cells and also activates HER-2-silence in SKBR-3 cells and ER-PR-silence in non TNB cells [142], and this indicates that the anti-proliferative effect of Kmp is initiated through estrogen receptor (ER)-dependent pathway which facilitates cell processes such as proliferation, development and differentiation [148]. The gene discussed is ESR1; the disease is cancer.