Kmp also increases the expression of non-receptor tyrosine-protein kinase (TYK-2), Janus kinase-1 (JAK-1), microtubule associated protein-1A-1B light chain-3 (MAPILC3), STAT1-2, autophagy related genes -5, -7 and -12, beclin-1 and phosphatase and tensin homolog (PTEN) and reduced the expression of cytokine signalling-3 (SOCS-3), PI3K-AKT-mTOR, miRNA-21, signal transducer and activator of transcription-3 (STAT-3), phosphorylated-mTOR signalling pathways and HIF1 in HCC [116,117,118,119]. Here, PTEN is linked to hepatocellular carcinoma.