NFKB1 and Alzheimer disease: Moreover, triggers of canonical and/or alternative NF-κB signaling pathways, such as pro-inflammatory cytokines [26], pattern-recognition receptors (PRRs) [27], T- and B-lymphocytes [28] as well as tumor necrosis factor (TNF) receptor superfamily [29], were also found to correlate with the progression of AD; thus, highlighting the central regulatory role of NF-κB in relation to BACE1 expression.