However, subsequent research has provided more insights into the molecular mechanisms meditating AD pathogenesis, highlighting the cross-talk between the formation of AD hallmarks and multiple other pathways; including but not limited to, neuro-inflammation [19], insulin signaling [20] oxidative stress [21] autophagy [22] tauopathies [23] and disrupted neuromodulatory control [24] among other pathways found to influence Aβ production. This evidence concerns the gene INS and Alzheimer disease.