In another study, a ruthenium phloretin complex resulted in the apoptosis of breast cancer cells via modulating p53 activity and p53-mediated activation of apoptotic events expedited by the p21, Cyt-C, caspase 9, cleaved caspase 3, Bax signaling and downregulating the Bcl-2 mediated signaling. This evidence concerns the gene TP53 and breast carcinoma.