CASP8 and malignant colon neoplasm: In another study, the treatment of colon cancer cells with phloretin resulted in the increased expression of Bax and the subsequent release of Cyt C and DIABLO/SMAC in the cytosol, resulting in the cleavage of caspases-8,9,3,7 and PARP, thereby causing apoptosis of colon cancer cells [13,39].