It was suggested that arbutin could inhibit osteosarcoma cell proliferation, migration and invasion via miR-338-3pl MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ Dependent) 1 Like) and by inactivating the AKT (protein kinase B)/mTOR (mammalian target of rapamycin) signaling pathway. The gene discussed is AKT1; the disease is osteosarcoma.