Given the importance of AhR signaling to gut immune cells [36] and the importance of gut immune cells in the pathogenesis of EAE and multiple sclerosis [37,38,39], it would be of great importance to explore whether the effects of PEGA on CNS autoimmunity can also be achieved by oral administration, and what effect PEGA has on gut immune cells. Here, AHR is linked to Autoimmunity.