Gao et al. found that remote limb ischemic postconditioning (RIPostC) attenuated apoptosis and protected mice from myocardial ischemia/reperfusion (IR) injury, possibly by activating the JAK/STAT3-mediated NRF2-antioxidant signaling pathway [143]. This evidence concerns the gene NFE2L2 and myocardial ischemia.