However, in human glioblastoma cells, PTEN loss leads to the downregulation of LIFRβ expression via Akt inhibition of FOXO3, STAT3 is no longer active, and its inhibition of IL8 gene is removed, leading to upregulation of IL8, which drives malignant glial transformation [93,94]. The gene discussed is CXCL8; the disease is glioblastoma.