Although IL4-producing immune cells (e.g., basophils, mast cells, and Th2 cells) play a crucial role in Th2-mediated immune diseases such as atopic dermatitis (AD) [10,34,35,36], DCs are also essential because they can initiate immune responses and modulate CD4+ T cell polarization [37]. The gene discussed is IL4; the disease is atopic eczema.