The aqueous extract of P. granatum fruit significantly raised the mRNA levels of IRS-1, Akt (Protein kinase B), GLUT-2, and GLUT-4, resulting in improved glucose uptake and storage and contributing to the regulation of both hyperglycemia and hyperlipidemia in alloxan-diabetic Wistar rats [146]. Here, AKT1 is linked to Hyperglycemia.