Specifically, it may be hypothesized that the SARS-CoV-2 S protein may impair NRP-1 molecular rearrangements that are necessary to the interaction with VEGF-A and VEGF-Rs, contributing to the increase in unbound (free) forms of VEGF-A observed during acute and long COVID-19 [101,102,130], which may be diverted to alternative pathways. This evidence concerns the gene NRP1 and COVID-19.