This view is supported by manifestations consistent with diffuse or organ-specific endotheliitis, altered nailfold capillaroscopy patterns in COVID-19 patients, and increases in markers of endothelial injury in blood samples from infected individuals, such as circulating endothelial cells (CECs), von Willebrand factor, soluble intercellular adhesion molecule-1 (sICAM-1), and angiopoietin-2 (Ang-2) [97,98,99,100]. Here, ANGPT2 is linked to COVID-19.