Therefore, the aim of this review is to summarize the evidence supporting this hypothesis and to discuss potential pitfalls by performing a literature search in PubMed and Google Scholar databases using combinations of the following terms: “SARS-CoV-2”; “COVID-19”; “long COVID-19”; “post-COVID-19” “COVID-19 vaccine”; “VEGF-A”; “neuropilin-1”. This evidence concerns the gene NRP1 and COVID-19.