Similarly, yersiniabactin (ybtE and fyuA), which is a major bacterial iron-uptake system, has been shown to promote oxidative stress [36] by triggering three signaling pathways that have been reported to be closely linked to CRC development [37]: the Janus kinases (JAK)/signal transducer and activator of transcription proteins (STAT), Wnt/β-catenin, and PI3K/AKT pathways. Here, AKT1 is linked to colorectal carcinoma.