As for advanced CRC, many pathways were identified, including ABC transporters, ubiquinone and terpenoid-quinone biosynthesis, a bacterial secretion system, pentose and glucuronate interconversions, ascorbate and aldarate metabolism, amino sugar and nucleotide sugar metabolism, the biosynthesis of cofactors, galactose metabolism, starch and sucrose metabolism, and microbial metabolism in diverse environments. Here, ABCG2 is linked to colorectal carcinoma.