Pathways that include targeted VFs detected in CRC III-IV: ABC transporters, ubiquinone and terpenoid-quinone biosynthesis, a bacterial secretion system, pentose and glucuronate interconversions, ascorbate and aldarate metabolism, amino sugar and nucleotide sugar metabolism, the biosynthesis of cofactors, galactose metabolism, starch and sucrose metabolism, and microbial metabolism in diverse environments. The gene discussed is ABCG2; the disease is colorectal carcinoma.