Likely, only B group PfEMP1s with a particularly strong binding affinity to CD36 or dual binding properties, as well as the increase in parasitemia and the accompanying stimulation of the immune system and the release of proinflammatory cytokines, lead to an activation of the endothelium and thus also to the presentation of other ECRs such as ICAM-1 or P-selectin. The gene discussed is CD36; the disease is parasitic infectious disease.