AGT and familial hypercholesterolemia: It involves the replacement of T nucleotide at position 704 of the second exon by the C nucleotide, resulting in the conversion of amino acid at position 235 from methionine (M) into threonine (T) [24]. The T allele of M235T most likely increases the risk of CAD in the presence of hypercholesterolemia because of the pleiotropic and proatherosclerotic characteristics of hypercholesterolemia and angiotensinogen derivatives [25].