It was found that VLDL + LDL in ApoE−/− mice increased significantly with the increase of the high-fat diet cycle compared with C57 mice, while in ApoE−/−;SAP−/− mice, the levels of VLDL + LDL were not statistically different from those in C57 mice, which indicated that SAP deficiency could improve the atherosclerosis by regulating the metabolism of VLDL + LDL. Here, APOE is linked to atherosclerosis.