Pridopidine, a DA stabilizer, could improve motor performance and result in neuroprotection in R6/2 mouse model of HD [45], upregulate the BDNF pathway and sigma 1 receptor (S1R) in Q175 knock-in (Q175 KI) vs. Q25 WT mouse models of HD [46]. The gene discussed is TMBIM4; the disease is Huntington disease.