DDR1 and Alzheimer disease: Nilotinib is a potent inhibitor of DDR1 (IC50 1 nM) [16,17,18,19,20,53] and it adequately enters the brain in PD (up to 4.12 nM) [21,22,23,34] and AD (up to 4.7 nM) [41] patients to inhibit DDR1.