Functionally a LAT1 inhibitor JPH203 or LAT1 KD by siRNA inhibits cell/tumor proliferation via mTOR in several thyroid cancer cell lines (8505C and OCUT-2/6) and in BRAFV600E;PIK3-CAH1047R and 8505C tumors [96,97]. The gene discussed is PIK3CG; the disease is thyroid gland carcinoma.