Higher expression of fatty acid synthesis enzymes through PCB (an enzyme involved in the anaplerotic flux into the TCA cycle by generating oxaloacetate from pyruvate (see above))-PI3K-Akt/mTOR-SREBP1c signaling pathway is also reported, and expression levels of PCB are positively correlated with thyroid cancer aggressiveness in patients with lymph node metastasis and in 8505C cells [56]. The gene discussed is MTOR; the disease is thyroid cancer.