This research reveals that PCNPs possess renoprotective activities in diabetic rats with nephropathy caused by STZ and also that PCNPs reduce hyperglycemia-induced oxidative stress, provocative markers such as TNF-α, IL-6, and KIM-1 in renal tissues, as well as GLUT-2 mRNA expression in the pancreas. The gene discussed is TNF; the disease is Hyperglycemia.