The genetic variant of patatin-like phospholipase domain-containing 3 rs738409 C > G p.I148M (PNPLA3I148M), which leads to the substitution of methionine for isoleucine at the 148th residue, is widely associated with nonalcoholic fatty liver disease (NAFLD) in various races. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.