For example, in patients with myalgic encephalomyelitis and chronic fatigue syndrome, which are challenging to diagnose, the amount of EVs in plasma increases, and actin network proteins such as talin-1 and filamin A, which are characteristically encapsulated, may serve as biomarkers [245,246,247]. The gene discussed is TLN1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.