Numerous data, based on pharmacological manipulations, indicate possible implications of HCN, Kir 2.x, and Ca2+-activated potassium channels in the pathological processes related to brain focal seizures and spreading depression [64,65,101] and cardiovascular ischemia/reperfusion events as atrial and ventricular arrhythmogenic activity and fibrosis [102,103,104,105,106]. The gene discussed is MALAT1; the disease is ischemia.