Considering that, in some cases, the diagnosis of leiomyomas can also imply specific and underlying genetic mutations (e.g., fumarate hydratase (FH) mutation in hereditary leiomyomatosis with renal cell carcinoma (RCC)), their rapid recognition by the clinicians is of primary importance [4]. The gene discussed is FH; the disease is hereditary leiomyomatosis and renal cell cancer.