Although CXCL16 and LOX-1 levels in the PBMCs from T2DM were not statistically significant, increased expression of CXCL16 in M1 macrophages [25] and increased expression of LOX-1 in M2-polarized macrophages have been observed which is consistent with the current model for increased lipid uptake in M2 macrophages [25,41]. The gene discussed is CXCL16; the disease is type 2 diabetes mellitus.