HSP expression might be induced by many stress factors, e.g., thermic stress (heat shock), chemical stress (heavy metals), oxidative stress (free radicals), denatured proteins, antibiotics, immunosuppressive drugs, hypoxia, nutritional inadequacy, and pathological conditions (inflammation, fever, viral and bacterial infections, carcinogenesis) [63,64,65]. Here, HSP90B2P is linked to bacterial infectious disease.