REN and obesity due to melanocortin 4 receptor deficiency: The researchers speculated that the reasons were that overweight and obesity patients were regarded as a risk group of CVD in advance; therefore, medicines such as a statin, aspirin, beta blocker, renin-angiotensin inhibitor, and hyperlipidemic agents were more proactively prescribed, and the fact that the average age of the overweight and obesity groups was 10–13 years younger than the underweight group acted as bias.