Anti-melanoma differentiation-associated gene 5 (Anti-MDA-5) autoantibodies were initially known as anti-CADM-140 antibodies, due to their presence in patients with Clinically Amyopathic DermatoMyositis (CADM), who were clinically asymptomatic for myositis [54]. The gene discussed is IFIH1; the disease is myositis disease.