In addition, the downregulation of a distinct set of genes including CTGF, LOX, MMP-1, PLG, TIMP-3, ITGA-1, ITGA-2 and CEBPB belonging to diverse biological pathways reveals the complexity of the molecular mechanisms involved in the pathogenesis of inflammation and fibrosis in CHC. The gene discussed is CEBPB; the disease is cryohydrocytosis.