Urate-lowering drugs are agents used to treat hyperuricaemia, capable of modulating the activity of key enzymes responsible for the metabolism and excretion of urates such as xanthine oxidoreductase (XO), urate transporter 1 [URAT1/SLC22A12] e glucose transporter 9 (GLUT9) [18]. The gene discussed is SLC22A12; the disease is hyperuricemia.