RUNX2 and hyperuricemia: Some reports indicate that hyperuricemia induces the differentiation of placenta-derived MSCs in neuronal cells in vitro [8], and other studies have reported the effect of UA on the osteogenic and adipogenic differentiation of human MSCs isolated from bone marrow (hBMSCs) through the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), alpha-1 subunit of nucleus binding factor, Cbfa1, Runx2, and Wnt signaling pathways [9,10].