SERPINE1 and metabolic disease: Comparing the characteristics of grade 1 (patients with abnormal liver function) to grade 4 (patients with liver injury), (Table 6) it can be observed that patients with liver injury grade 4 were obese or overweight males, with a longer hospitalization period, a more evident inflammatory syndrome (CRP, serum ferritin, ESR, IL-6), presenting metabolic disorders (TG, glycemia, HbA1C with higher serum values), more important coagulation/fibrinolysis changes (higher values for PAI-1 and fibrinogen) and higher LDH values than the patients with grade 1 with abnormal liver function.