Considering that the advance of MBG nanoparticles is well-established in the literature and already improves drug loading and controlled release, their functionalization with molecules, such as quercetin and LY364947, aiming at overcoming the barriers caused by tumor stroma, or the functionalization with glycoprotein CD47 to override some protein corona effects, are some examples of glass functionalization yet to be explored and might lead to improved outcomes in in vivo studies. The gene discussed is CD47; the disease is neoplasm.