A third type is defined as immune-exhausted HCC and contains a particular tumor-immune microenvironment (TIME), characterized by T cell exhaustion, the infiltration of the macrophage and fibroblasts and the activation of TGFbeta signaling, together with intra-tumor fibrosis and a high degree of intra-tumor steatosis [26]. This evidence concerns the gene TGFB1 and neoplasm.