In this study, we aimed to better understand the involvement of CD36 and the FA metabolism of CRC by analyzing the gene expression levels of CD36, GPC4, FASN, SLC27A3, and SLC27A4 in 39 paired tumoral and peritumoral tissues from patients with CRC compared with 18 normal colonic samples as well as a panel of seven miRNAs targeting CD36 and most of the investigated genes. This evidence concerns the gene GPC4 and colorectal carcinoma.