The study reports an association between incident HF and concentrations of hs-cTnI >0.018 μg/L, BNP >50 ng/L, cystatin C >0.93 nmol/L, D-dimer >273 nmol/L, hs-CRP >4.8 nmol/L and demonstrates that adding these biomarkers to a clinical prediction model improves risk stratification. The gene discussed is TNNI3; the disease is hydrops fetalis.