Compounded prediction models including both hs-cTnI and hs-cTnT, in addition to the standard pooled cohort equation model (a 10-year risk assessment equation for atherosclerotic CVD), improved the prediction of incident events reflected in increases of AUC compared to the pooled cohort equation model alone (ΔAUC 0.019 for ASCVD, 0.026 for global CVD and 0.035 for HF) [31]. This evidence concerns the gene TNNT2 and hydrops fetalis.