NPPB and keratoconus: Finally, 7-KC improved the integrated discrimination and category-free net reclassification of existing models based on traditional risk factors alone (0.053 [0.026–0.083] and 0.400 [0.230–0.560], respectively) or in combination with NT-proBNP and hs-CRP (0.015 [0.006–0.032] and 0.140 [0.015–0.300], respectively) [44].