NT-proBNP and D-dimers together provided incremental value when added to the GRACE score for all-cause death, while for MACEs (all-cause death, hospital admission for unstable angina, hospital admission for heart failure, nonfatal recurrent myocardial infarction, and stroke), the predictive value was improved when fibrinogen was also added to the model [22]. This evidence concerns the gene NPPB and stroke disorder.