NPPB and ischemic stroke: Among patients with HFrEF, those with higher NT-proBNP levels (≥644 pg/mL for LVEF <40%; ≥534 pg/mL for LVEF 40–49%; ≥321 pg/mL for LVEF ≥50%) had a five-fold increased risk of ischemic stroke, while elevated NT-proBNP was associated with all-cause mortality in both HFpEF and HFrEF patients [21].