In a substudy of the Multi-Ethnic Study of Atherosclerosis (MESA) trial, including 6814 participants without CVD followed for 12 years, among 735 different variables, NT-proBNP had the 4th, 3rd, and 1st relative variable importance as predictor of CAD, all CVD types, and HF, respectively [4]. The gene discussed is NPPB; the disease is coronary artery disorder.