Recently, de Miguel Perez et al. evaluated the prognostic role of plasma EV PD-L1 expression in a retrospective cohort of 33 NSCLC patients treated with ICIs and validated it in a prospective analysis of a cohort of 39 patients enrolled in the phase 2 PROLUNG trial with pembrolizumab and docetaxel or docetaxel alone [43]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.