Yang et al. conducted a study to evaluate the correlation between tumor tissue PD-L1 (tPD-L1) and blood PD-L1 (bPD-L1), including PD-L1 mRNA, exoPD-L1 and soluble PD-L1(sPD-L1) and to monitor their changes during ICIs treatment in 51 cancer patients of which 40 had advanced NSCLC [39]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.