According to the latest ESC/EACTS guidelines for the management of valvular disease, intervention for severe AS is indicated, irrespective of symptoms, in patients with one of these conditions, either isolated or associated: systolic dysfunction in absence of other causes; severe AS with mean gradient ≥ 60 mmHg; rapid progression and markedly elevated BNP levels, particularly in those with estimated poor prognosis [9]. Here, NPPB is linked to aortic valve stenosis.