Although intravenous butyrate infusion reduced the inflammatory response in our rat model of faecal peritonitis-induced sepsis, supplemental butyrate may be associated with deleterious effects in early sepsis as butyrate administration was associated with cardio depressant effects, increased lactate levels, increased splenocyte ROS, and impaired LPS-induced IL-10 release. This evidence concerns the gene IL10 and Sepsis.