Authors put forth the concept that obesity and metabolic factors such as lipids, insulin, glucose, and leptin affect placental function and increase the risk of developing hypertension in pregnancy by reducing placental perfusion, enhancing placental release of soluble factors, and by increasing the sensitivity of the maternal vasculature to placental ischemia-induced soluble factors [9]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.