Two subtypes of HGSOC were identified, which significantly differ in the level of expression of the progesterone receptor in the tumor tissue, the secretion of miR-16-5p, miR-17-5p, miR-93-5p and miR-20a-5p, and the level of serum CA125, tumor size, surgical outcome (optimal or suboptimal cytoreduction) and response to chemotherapy. The gene discussed is MUC16; the disease is neoplasm.