It is believed that HGSOC, in contrast to other ovarian cancer subtypes, originates predominantly from serous tubal intraepithelial carcinomas (STICs) possessing TP53 mutations and showing little to no proliferative activity under the PGR regulation of DREAM complex genes, repressing 900 cell cycle genes [51]. This evidence concerns the gene KCNIP3 and ovarian carcinoma.