In light of this fact, it is not excluded that the possibility of increased EMT under decreased CA125 and the upregulation of miR-16-5p, miR-17-5p, miR-93-5p and miR-20a-5p in the case of PGR-negative HGSOC results in a smaller tumor size, unresectable tumor and worse survival compared to PGR-positive HGSOC. This evidence concerns the gene MUC16 and neoplasm.